Underwater Breathing means you don’t ever have to worry about drowning damage while searching for sunken treasure. Resist disease reduces the chance of getting a disease from an animal or trap. You can keep attacking enemies while this Power does its work, no focus required. It can bring your character back from the bring death. Histskin is one of the best abilities to have in Skyrim.
The tone and color of some dialogue change depending on your race. Orcs are welcomed in the Orc Strongholds while other races must prove themselves. But these differences in gameplay are quite minor, for example, when infiltrating the Thalmor Embassy dressed in the High Elf faction robes, you will find it easier to sneak around undetected compared to other races. Choosing the best Skyrim race depends on what type of gameplay you want in The Elder Scrolls V.